Endocrine Abstracts

Background: To minimize potential harm from overtreatment of low-risk thyroid cancers, the 2015 American Thyroid Association (ATA) Guidelines recommend that radioactive iodine (RAI) ablation should not be routinely used in low-risk differentiated thyroid carcinoma (DTC). The present study aims to evaluate trends in RAI therapy in a tertiary center after the update of these Guidelines.Methods: Data from patients followed in a tertiary center with low-risk...

Introduction: Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group with various treatment options depending on grading, staging, and presence of symptoms related to hormonal secretion. Their incidence significantly increased over the past decade and nowadays constitutes 30% of all NETs of the gastrointestinal tract. Despite the evidence of a different malignancy potential of PNETs G2, postoperative management is the same in all patients. Ai...

Background: Animal-derived protein consumption has been rising globally, driven by socioeconomic factors and shifts in dietary patterns to improve performance and support weight loss. In recent years an increasing trend has been observed for plant-based proteins due to sustainability concerns. Previous studies indicate that the metabolic effects of proteins may vary according to their origin. Thus, the aim of this single-blind, crossover study was to assess the acute effects o...

Introduction: In adults, treatment of growth hormone deficiency (GHD) with daily recombinant human growth hormone (GH) injections has shown to improve many clinical features associated with GHD. Currently, many adults with GHD receive GH indefinitely, even when they fail to report any obvious benefits from this treatment. Additionally, evidence on the impact of discontinuing long-term GH therapy is limited. We conducted a survey of UK endocrine clinicians (doctors and speciali...

Background: The best lateralization method to ascertain cure after surgery in unilateral primary aldosteronism (PA) is debated. Risk of persistent of PA in those with non-classical adrenal histopathology remains poorly characterized.Objective: We examined the value of anatomical compared with functional subtyping and the significance of immunohistochemical analysis of CYP11B1 and CYP11B2 for the outcome and histopathological diagnosis of primary aldoster...

Introduction: Somatostatin analogues (SA) are the first-line treatment for Acromegaly in patients whose surgery failed to achieve cure or it was contraindicated. The main reported adverse events of SA are mild and transient, and include nausea, abdominal cramps, diarrhea and flatulence. Other side effects are of rare occurrence.Case report: The authors describe a case of a 44-year-old previously asymptomatic male patient with a growth hormone-secreting p...

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing’s syndrome (CS). It is a highly heterogeneous disease with multiple adrenal macronodules and variable levels of cortisol excess. The pathogenesis is complex and different mechanisms such as aberrant hormone receptors, local production of ACTH in adrenal tissues and genetic mutations have been identified. The approach is not well established. Nine patients with PBMAH who are currently fol...

Introduction: Black adrenal adenomas are rare and benign. They are named after their black appearance, due to lipofuscin pigment. Most frequently black adenomas are associated with ACTH-independent Cushing’s syndrome. They can also cause primary hyperaldosteronism or be nonfunctioning. Unlike most other adrenal adenomas, black adenomas exhibit high Hounsfield units (>30) on CT, and high standard uptake value on FDG-PET.Case presentation: A 67-ye...

Introduction: The small-cell neuroendocrine prostate carcinoma (SCPC) is rare, highly aggressive and usually transforms from prostate adenocarcinoma (PAC) after androgen deprivation therapy (ADT).Case Report: A 66-year-old man had a three-year history of high-grade PAC with high burden disease (abdominal lymph node and bone metastasis) at presentation (09/2019). On the initial staging evaluation, the CT scan documented a 20 mm left adrenal nodule compati...

Introduction: Hypercalcemia is not uncommon in clinical practice and may present as a life-threatening emergency. Its main aetiologies are primary hyperparathyroidism (80% parathyroid adenomas; 20% multiglandular hyperplasia, <1% parathyroid carcinomas) and hypercalcemia of malignancy, with or without presence of bone metastases.Case Report: We present a case of a 77 years-old male, submitted to a subtotal gastrectomy at the age of 73 due to a perfor...